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CBD and the Endocannabinoid System (ECS)
Cannabidiol, or CBD, is a non-psychoactive cannabinoid found in hemp. CBD is one of over 100+ cannabinoids found in the cannabis plant. Unlike many of the other cannabinoids, CBD hemp strains have been bred so that CBD occurs in significant quantities; therefore, it is relatively easily extracted from these strains.
Discovered in the late 1980s, the Endocannabinoid System, or ECS is a biological system found in all mammals, composed of endocannabinoids and cannabinoid receptors. The ECS is believed to have more cellular receptor sites than any other receptor system. The widespread distribution of these cannabinoid receptors shows just how important the ECS is to our overall bodily function and health.
Endocannabinoids are endogenous neurotransmitters that are produced by our bodies. They regulate neurotransmission and allow for feedback loops. Anandamide and 2-Arachidonoylglycerol (2-AG) are the two primary endocannabinoids.
Phytocannabinoids are plant derivative compounds (primarily extracted from cannabis) that mimic the characteristics of the endocannabinoids. THC and Cannabidiol (CBD) are the two primary phytocannabinoids that mimic the endocannabinoids Anandamide and 2-AG, respectively. Both endocannabinoid and phytocannabinoids, collectively referred to as cannabinoids, bind to cannabinoid receptors that exist throughout the mammalian body.
Our ECS includes two primary cell cannabinoid receptors, CB1 and CB2. While these receptors are found throughout the body, they tend to concentrate in certain areas. CB1 receptors are abundant in the brain, while CB2 receptors are more often found on immune cells, in the gastrointestinal tract, and in the peripheral nervous system. The endocannabinoid Anandamide, as well the phytocannabinoid THC target CB1 receptors, predominantly found in the brain and nervous system, as well as in peripheral organs and tissues. The other main endocannabinoid 2-Arachidonoylglycerol (2-AG) and its own mimetic phytocannabinoid, CBD, are active at both CB1 and CB2 cannabinoid receptors.
Not all Hemp Products Are Created Equal
Hemp has over 10,000 known uses, which can be made from both the female or male plants, depending on the desired product. Mana Artisan Botanics™ uses only female hemp plants in our products, with lab testing guaranteeing below 0.3% THC levels.
Hemp extract is the phytocannabinoid concentrate, created through some form of the extraction process, most commonly either with supercritical carbon dioxide or ethanol. The extract’s potency will depend on the levels of cannabinoids in the plant, so each batch of extract will have different levels of cannabinoids.
Both Hemp and Marijuana are in the cannabis family. Human intervention has produced variation within the species in terms of THC and CBD levels. The 2018 Farm Bill designates hemp as having THC levels below 0.3%. Marijuana is always harvested from female plants and typically has high THC levels with little to no CBD, although some strains can contain verifying levels of CBD/THC ratios. Hemp has over 10,000 known uses, which can be made from both the female or male plant depending on the desired product. Mana Artisan Botanics uses only female hemp plants in our products, with lab testing guaranteeing below 0.3% THC levels.
Hemp extract is the phytocannabinoid concentrate, created through some form of extraction process, most commonly either with supercritical carbon dioxide or ethanol. The extract’s potency will depend on the levels of cannabinoids in the plant, so each batch of extract will have different levels of cannabinoids.
The demand for hemp extracts is rapidly increasing in the U.S. However, there is still limited supply of U.S.-grown hemp, resulting in high prices that cannot compete against imported hemp extract from places like China or Eastern Europe. Consumers seeking quality products may find a lack of transparency when it comes to the origin of the hemp extract in their products. And unfortunately, there is limited data behind the volume and quality control behind these imported hemp extracts. At Mana Artisan Botanics, we take great care to source high-quality hemp that is grown in the USA using sustainable practices.
In the cannabis industry much of what is grown, unless it is organic, is sprayed with varying levels of pesticides and fungicides. Most consumers don’t realize this is a common practice. Given the increasing demand for hemp and cannabis, many conventional farmers are transitioning their fields to these high value crops. Yet, hemp’s cultivation environment is critical as it can act as a bio-remediation crop, absorbing contaminants from the soil while it grows. If the hemp was grown in poor or misused soil, that plant might contain toxins you won’t want to ingest.
This is why at Mana Artisan Botanics, we source our CBD-rich hemp extract only from farms that have never had any toxic agriculture on the land or use any harmful pesticides or fungicides. All our products are purity and potency tested at multiple lab facilities for cannabinoid levels as well as pesticide residue, heavy metals and other contaminants. State of the art testing methods are used and THC levels are guaranteed to be under the federal limit of 0.3%. If you want to review the lab results, please email us at firstname.lastname@example.org!
Many of the hemp products on the market derive their CBDs as a by-product from other types of hemp varieties such as fiber or seed for hemp food products. The levels of CBD-rich hemp extract in these products are lower and lack the diverse spectrum of cannabinoids. At Mana Artisan Botanics, the hemp we source is grown with great care to facilitate high levels of the non-psychoactive cannabinoids.
Full-spectrum extracts contain all the phytochemicals naturally found in the cannabis plant, including CBD, other cannabinoids and terpenes. Legal hemp derived full-spectrum extracts have a THC content below 0.3%. The full spectrum of the active compounds work together synergistically to amplify the effects and increase the efficacy of the individual components. This phenomenon is referred to as the entourage effect.
Broad-spectrum extracts contain CBD and all the other compounds within the plant, including terpenes and other cannabinoids, with the exception of THC. Broad-spectrum extracts, like full-spectrum extracts, can produce the entourage effect.
CBD isolate is a single molecule chemical extraction of the cannabis plant that contains only CBD. Science now shows that the body prefers a whole plant food/medicine over a refined or isolated version as is demonstrated by the entourage effect. The long term health impacts of the use of CBD isolates is unknown.
Mana has been dedicated from day one to creating the most wholesome products possible. With over 25 years in the wellness and cannabis arenas, it was a clear preference to not use isolates in our products. We believe the cannabis plant in its fullness is more compatible and beneficial for the body and it’s endocannabinoid system then a chemically stripped-down single-molecule white powder, which is CBD isolate. The entourage effect has been a desired result we have wished to create from the start.
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